Cyclic acetal formation between 2-pyridinecarboxyaldehyde and γ-hydroxy-α,β-acetylenic esters

Chemoselective Reaction Between 5,5-Diarylhydantoins and Acetylenic Esters in the Presence of Trialkyl Phosphite

The adducts produced in the reaction between trialkyl phosphites and acetylenic esters were trapped by hydantoins to produce highly functionalized dialkyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl) succinate in good yields.

AMild Method for the Preparation of g-Hydroxy- a,b-Acetylenic Esters**

The alkynylation of a carbonyl compound is a powerful reaction for forming a carbon–carbon s bond. Highly functionalized g-hydroxy-a,b-acetylenic esters RCH(OH)C C CO2Me (A) are promising synthetic intermediates that can be used as precursors to a variety of complex molecules. Since the procedure was reported by Midland et al., alcohols A have mainly been prepared by the treatment of aldehydes ...

chemoselective reaction between 5,5-diarylhydantoins and acetylenic esters in the presence of trialkyl phosphite

the adducts produced in the reaction between trialkyl phosphites and acetylenic esters were trapped by hydantoins to produce highly functionalized dialkyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl) succinate in good yields.

Copper‐Catalyzed Borylation of Cyclic Sulfamidates: Access to Enantiomerically Pure (β‐and γ‐Amino­alkyl)boronic Esters

Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro.

trans-4-Hydroxy-2-hexenal (t-4HH), a reactive metabolite isolated from the pyrrolizidine alkaloid senecionine, and trans-4-hydroxy-2-nonenal (t-4HN), a product of lipid peroxidation, reacted nonenzymatically with deoxyguanosine at pH 7.4 at 37 degrees C in vitro with each compound yielding two pairs of diastereomeric adducts. Adducts were isolated using reverse phase high-performance liquid chr...